Recombinant Human F-box only protein 31 (FBXO31)

Uniprot Id

Q5XUX0

Target Species

Human

Target Name

FBXO31

Target Full Name

F-box only protein 31

Target Function

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

Target Involvement

Mental retardation, autosomal recessive 45 (MRT45)

Target Protein Families

FBXO31 family

Target Tissue Specificity

Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.

Target Synonyms

DKFZp434B027; DKFZp434J1815; F box only protein 31; F box protein 31; F-box only protein 31; FBX14; FBX31 ; FBX31_HUMAN; FBXO14 ; Fbxo31; FLJ22477; MGC15419; MGC9527; pp2386 ; Putative breast cancer tumor suppressor; SCF ubiquitin ligase specificity factor

Target Background

This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants.