Recombinant Human Fibrinogen-like protein 1 (FGL1), Truncated

Uniprot Id

Q08830

Target Species

Human

Target Name

FGL1

Target Full Name

Fibrinogen-like protein 1

Target Function

Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes.

Target Subcellular Location

Secreted.

Target Tissue Specificity

Under normal conditions, liver-specific.

Target Research Area

Cardiovascular

Target Synonyms

(HP-041)(Hepassocin)(HPS)(Hepatocyte-derived fibrinogen-related protein 1)(HFREP-1)(Liver fibrinogen-related protein 1)(LFIRE-1)

Target Background

Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.