Recombinant Human Fibroblast growth factor 3 (FGF3)

Uniprot Id

P11487

Target Species

Human

Target Name

FGF3

Target Full Name

Fibroblast growth factor 3

Target Function

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development.

Target Involvement

Deafness with labyrinthine aplasia, microtia and microdontia (LAMM)

Target Subcellular Location

Secreted.

Target Protein Families

Heparin-binding growth factors family

Target Research Area

Others

Target Synonyms

FGF3; INT2Fibroblast growth factor 3; FGF-3; Heparin-binding growth factor 3; HBGF-3; Proto-oncogene Int-2

Target Background

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.