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Amino acids 2-338 constitute the expression domain of recombinant Human FBP1. The theoretical molecular weight of the FBP1 protein is 56.7 kDa. This FBP1 recombinant protein is manufactured in e.coli. The FBP1 gene fragment has been modified by fusing the N-terminal 10xHis-SUMO tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant FBP1 protein during the following stages.Human Fructose-1,6-Bisphosphatase 1 (FBP1) is a key enzyme in gluconeogenesis, playing a pivotal role in maintaining glucose homeostasis. FBP1 catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate, a critical step in the generation of glucose from non-carbohydrate precursors. Beyond its role in gluconeogenesis, FBP1 is implicated in various physiological processes, including hepatic glucose production, energy metabolism, and insulin sensitivity. Dysregulation of FBP1 is associated with metabolic disorders, such as type 2 diabetes. Research areas involving FBP1 encompass metabolic pathways, glucose metabolism, and potential therapeutic interventions for metabolic diseases. Understanding FBP1 function contributes to unraveling the complexities of metabolic regulation.
Amino acids 2-338 constitute the expression domain of recombinant Human FBP1. The theoretical molecular weight of the FBP1 protein is 56.7 kDa. This FBP1 recombinant protein is manufactured in e.coli. The FBP1 gene fragment has been modified by fusing the N-terminal 10xHis-SUMO tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant FBP1 protein during the following stages.Human Fructose-1,6-Bisphosphatase 1 (FBP1) is a key enzyme in gluconeogenesis, playing a pivotal role in maintaining glucose homeostasis. FBP1 catalyzes the hydrolysis of fructose-1,6-bisphosphate to fructose-6-phosphate and inorganic phosphate, a critical step in the generation of glucose from non-carbohydrate precursors. Beyond its role in gluconeogenesis, FBP1 is implicated in various physiological processes, including hepatic glucose production, energy metabolism, and insulin sensitivity. Dysregulation of FBP1 is associated with metabolic disorders, such as type 2 diabetes. Research areas involving FBP1 encompass metabolic pathways, glucose metabolism, and potential therapeutic interventions for metabolic diseases. Understanding FBP1 function contributes to unraveling the complexities of metabolic regulation.
| Cat.No | ACP02423 | Target Name | FBP1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-338aa | Mol Weight | 56.7kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P09467 |
|---|
Uniprot Id
P09467
Target Species
Human
Target Name
FBP1
Target Full Name
Fructose-1,6-bisphosphatase 1
Target Function
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Target Involvement
Fructose-1,6-bisphosphatase deficiency (FBP1D)
Target Protein Families
FBPase class 1 family
Target Tissue Specificity
Expressed in pancreatic islets.
Target Research Area
Signal Transduction, Epigenetics and Nuclear Signaling
Target Synonyms
6-bisphosphatase 1; 6-bisphosphate 1-phosphohydrolase 1; D fructose 1 6 bisphosphate 1 phosphohydrolase 1; D-fructose-1; EC 3.1.3.11; F16P1_HUMAN; FBP; FBP 1; FBP1; FBPase 1; Fructose 1 6 bisphosphatase 1; Fructose bisphosphatase 1; Fructose-1; Growth inhibiting protein 17; Liver fructose bisphosphatase
Target Background
Fructose-1, 6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1, 6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1, 6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.
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