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Recombinant Human Gap junction alpha-8 protein (GJA8), Truncated

ACP06942

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP06942 Target NameGJA8
Target SynonymsGJA8; Gap junction alpha-8 protein; Connexin-50; Cx50; Lens fiber protein MP70FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Protein LengthPartial
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDP48165
Background Information
  • Uniprot Id

    P48165

  • Target Species

    Human

  • Target Name

    GJA8

  • Target Full Name

    Gap junction alpha-8 protein

  • Target Function

    Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.

  • Target Involvement

    Cataract 1, multiple types (CTRCT1)

  • Target Subcellular Location

    Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

  • Target Protein Families

    Connexin family, Alpha-type (group II) subfamily

  • Target Tissue Specificity

    Eye lens.

  • Target Synonyms

    GJA8; Gap junction alpha-8 protein; Connexin-50; Cx50; Lens fiber protein MP70

  • Target Background

    This gene encodes a transmembrane connexin protein that is necessary for lens growth and maturation of lens fiber cells. The encoded protein is a component of gap junction channels and functions in a calcium and pH-dependent manner. Mutations in this gene have been associated with zonular pulverulent cataracts, nuclear progressive cataracts, and cataract-microcornea syndrome.

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