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| Cat.No | ACP07048 | Target Name | GJB2 |
|---|---|---|---|
| Target Synonyms | GJB2; Gap junction beta-2 protein; Connexin-26; Cx26 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P29033 |
|---|
Uniprot Id
P29033
Target Species
Human
Target Name
GJB2
Target Full Name
Gap junction beta-2 protein
Target Function
Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Target Involvement
Deafness, autosomal recessive, 1A (DFNB1A); Deafness, autosomal dominant, 3A (DFNA3A); Vohwinkel syndrome (VOWNKL); Keratoderma, palmoplantar, with deafness (PPKDFN); Keratitis-ichthyosis-deafness syndrome (KID syndrome); Bart-Pumphrey syndrome (BPS); Ichthyosis hystrix-like with deafness syndrome (HID syndrome)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Target Protein Families
Connexin family, Beta-type (group I) subfamily
Target Synonyms
GJB2; Gap junction beta-2 protein; Connexin-26; Cx26
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