Recombinant Human Gastrin-releasing peptide receptor (GRPR)

Cat.No	ACP00042	Target Name	GRPR
Target Synonyms	GRP-R;GRP-preferring bombesin receptor	Form	Liquid or Lyophilized powder
Expression System	in vitro E.coli expression system	Expression Range	1-384aa
Mol Weight	44.2 kDa	Protein Length	Full length
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00042

Target Name

GRPR

Target Synonyms

GRP-R;GRP-preferring bombesin receptor

Form

Liquid or Lyophilized powder

Expression System

in vitro E.coli expression system

Expression Range

1-384aa

Mol Weight

44.2 kDa

Protein Length

Full length

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P30550

Background Information

Uniprot Id

P30550
Target Species

Human
Target Name

GRPR
Target Full Name

Gastrin-releasing peptide receptor
Target Function

Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory.
Target Subcellular Location

Cell membrane; Multi-pass membrane protein.
Target Protein Families

G-protein coupled receptor 1 family
Target Tissue Specificity

Highly expressed in pancreas. Also expressed in stomach, adrenal cortex and brain.
Target Research Area

Neuroscience
Target Synonyms

BB2; Bombesin BB2 receptor; bombesin receptor 2; Gastrin Releasing Peptide Receptor; Gastrin-releasing peptide receptor; GRP preferring bombesin receptor; GRP R; GRP-preferring bombesin receptor; GRP-R; Grp/bombesin receptor; Grpr; GRPR_HUMAN
Target Background

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

Recombinant Human Gastrin-releasing peptide receptor (GRPR)

Specifications

Immunogen Information

Inquire Recombinant Human Gastrin-releasing peptide receptor (GRPR) Now

Related Products