Recombinant Human Glomulin (GLMN)

Cat.No	ACP13259	Target Name	GLMN
Target Synonyms	48-KD; FKBP-associated protein, 68-KD; FKBPAP; GLML; Glmn; GLMN_HUMAN; Glomulin; glomulin, FAP; FAP48; FAP68; FK506 binding protein associated protein; FK506-binding protein-associated protein; FKBP associated protein; FKBP-associated protein; FKBP-associated protein, FKBP associated protein; GVM; VMGLOM	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	2-594
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP13259

Target Name

GLMN

Target Synonyms

48-KD; FKBP-associated protein, 68-KD; FKBPAP; GLML; Glmn; GLMN_HUMAN; Glomulin; glomulin, FAP; FAP48; FAP68; FK506 binding protein associated protein; FK506-binding protein-associated protein; FKBP associated protein; FKBP-associated protein; FKBP-associated protein, FKBP associated protein; GVM; VMGLOM

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

2-594

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q92990

Background Information

Uniprot Id

Q92990
Target Species

Human
Target Name

GLMN
Target Full Name

Glomulin
Target Function

Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1. Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels. Essential for normal development of the vasculature. Contributes to the regulation of RPS6KB1 phosphorylation.
Target Involvement

Glomuvenous malformations (GVMs)
Target Tissue Specificity

Ubiquitous.
Target Synonyms

FAP; FAP48; FAP68; FK506 binding protein associated protein; FK506-binding protein-associated protein; FKBP associated protein; FKBP-associated protein; FKBP-associated protein, 48-KD; FKBP-associated protein, 68-KD; FKBPAP; GLML; Glmn; GLMN_HUMAN; Glomulin; glomulin, FKBP associated protein; GVM; VMGLOM
Target Background

This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene.

Recombinant Human Glomulin (GLMN)

Specifications

Immunogen Information

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