Recombinant Human Glutamate receptor delta-2 subunit (GRID2), Truncated

Cat.No	ACP05395	Target Name	GRID2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05395

Target Name

GRID2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O43424

Background Information

Uniprot Id

O43424
Target Species

Human
Target Name

GRID2
Target Full Name

Glutamate receptor ionotropic, delta-2
Target Function

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex.
Target Involvement

Spinocerebellar ataxia, autosomal recessive, 18 (SCAR18)
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Target Protein Families

Glutamate-gated ion channel (TC 1.A.10.1) family, GRID2 subfamily
Target Synonyms

delta-2; GluD2; GLUR D2; GluR delta 2; GluR delta-2 subunit; GLURD 2; GLURD2; Glutamate receptor delta 2 subunit ; Glutamate receptor ionotropic; Glutamate receptor ionotropic delta 2; GRID 2; Grid2; GRID2_HUMAN; MGC117022; MGC117023; MGC117024
Target Background

The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans.

Recombinant Human Glutamate receptor delta-2 subunit (GRID2), Truncated

Specifications

Immunogen Information

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