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| Cat.No | ACP06345 | Target Name | FAM20B |
|---|---|---|---|
| Target Synonyms | FAM20B; KIAA0475; Glycosaminoglycan xylosylkinase; Xylose kinase | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75063 |
|---|
Uniprot Id
O75063
Target Species
Human
Target Name
FAM20B
Target Full Name
Glycosaminoglycan xylosylkinase
Target Function
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein.
Target Protein Families
FAM20 family
Target Tissue Specificity
Widely expressed. Strongly expressed in pancreas, spleen and fetal liver.
Target Synonyms
FAM20B; KIAA0475; Glycosaminoglycan xylosylkinase; Xylose kinase
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