Recombinant Human Golgi to ER traffic protein 4 homolog (GET4)

Cat.No	ACP16160	Target Name	GET4
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	2-327	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP16160

Target Name

GET4

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

2-327

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q7L5D6

Background Information

Uniprot Id

Q7L5D6
Target Species

Human
Target Name

GET4
Target Full Name

Golgi to ER traffic protein 4 homolog
Target Function

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome
Target Subcellular Location

Cytoplasm, cytosol.
Target Protein Families

GET4 family
Target Synonyms

C7orf20; CGI 20; CGI20; Conserved edge expressed protein; Conserved edge protein; Conserved edge-expressed protein; GET 4; GET4; GET4_HUMAN; Golgi to ER traffic protein 4 homolog (S. cerevisiae); Golgi to ER traffic protein 4 homolog; Transmembrane domain recognition complex 35 kDa subunit; Transmembrane domain recognition complex 35kDa; TRC35; UPF0363 protein C7orf20

Recombinant Human Golgi to ER traffic protein 4 homolog (GET4)

Specifications

Immunogen Information

Inquire Recombinant Human Golgi to ER traffic protein 4 homolog (GET4) Now

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