Recombinant Human GPI mannosyltransferase 4 (PIGZ), Truncated

Uniprot Id

Q86VD9

Target Species

Human

Target Name

PIGZ

Target Full Name

GPI mannosyltransferase 4

Target Function

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

Glycosyltransferase 22 family, PIGZ subfamily

Target Tissue Specificity

Widely expressed at low level, with highest level in brain and colon.

Target Synonyms

PIGZ; SMP3; GPI mannosyltransferase 4; EC 2.4.1.-; GPI mannosyltransferase IV; GPI-MT-IV; Phosphatidylinositol-glycan biosynthesis class Z protein; PIG-Z; SMP3 homolog; hSMP3

Target Background

The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors.