Recombinant Human GTP-binding protein 10 (GTPBP10)

Uniprot Id

A4D1E9

Target Species

Human

Target Name

GTPBP10

Target Full Name

GTP-binding protein 10

Target Function

May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorganization of the nucleolar architecture is observed.

Target Subcellular Location

Nucleus, nucleolus. Chromosome. Note=Found in the dense fibrillar compartment region of the nucleolus. At the onset of mitosis moves to the chromosome surface and remains there until anaphase. Gradually re-assembles into the nucleolus at late anaphase to telophase.

Target Protein Families

TRAFAC class OBG-HflX-like GTPase superfamily, OBG GTPase family

Target Synonyms

GTPBP10; OBGH2; UG0751c10GTP-binding protein 10; Protein obg homolog 2; ObgH2

Target Background

Small G proteins, such as GTPBP10, act as molecular switches that play crucial roles in the regulation of fundamental cellular processes such as protein synthesis, nuclear transport, membrane trafficking, and signal transduction (Hirano et al., 2006 [PubMed 17054726]).