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| Cat.No | ACP03938 | Target Name | GNL3L |
|---|---|---|---|
| Target Synonyms | GNL3LGuanine nucleotide-binding protein-like 3-like protein | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-582aa |
| Mol Weight | 81.6kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NVN8 |
|---|
Uniprot Id
Q9NVN8
Target Species
Human
Target Name
GNL3L
Target Full Name
Guanine nucleotide-binding protein-like 3-like protein
Target Function
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Target Subcellular Location
Nucleus, nucleolus.
Target Protein Families
TRAFAC class YlqF/YawG GTPase family
Target Research Area
Others
Target Synonyms
GNL3LGuanine nucleotide-binding protein-like 3-like protein
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