Recombinant Human Guanylyl cyclase-activating protein 2 (GUCA1B)

Uniprot Id

Q9UMX6

Target Species

Human

Target Name

GUCA1B

Target Full Name

Guanylyl cyclase-activating protein 2

Target Function

Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor response and recovery of response in bright light.

Target Involvement

Retinitis pigmentosa 48 (RP48)

Target Subcellular Location

Cell membrane; Lipid-anchor. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment.

Target Tissue Specificity

In the retina, it is expressed in cone and rod photoreceptor cells.

Target Synonyms

GCAP 2; Guanylate Cyclase Activating Protein Photoreceptor 2; Guanylate cyclase activator 1B; Guanylin 2; Guanylyl cyclase-activating protein 2; GUC1B_HUMAN; GUCA 2; Guca1b

Target Background

The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa.