Recombinant Human Hematopoietic progenitor cell antigen CD34 (CD34), Truncated

Uniprot Id

P28906

Target Species

Human

Target Name

CD34

Target Full Name

Hematopoietic progenitor cell antigen CD34

Target Function

Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

CD34 family

Target Tissue Specificity

Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

Target Synonyms

CD34; Hematopoietic progenitor cell antigen CD34; CD antigen CD34

Target Background

The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene.