Recombinant Human Heparin cofactor 2 (SERPIND1)

Uniprot Id

P05546

Target Species

Human

Target Name

SERPIND1

Target Full Name

Heparin cofactor 2

Target Function

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.; Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

Target Involvement

Thrombophilia due to heparin cofactor 2 deficiency (THPH10)

Target Protein Families

Serpin family

Target Tissue Specificity

Expressed predominantly in liver. Also present in plasma.

Target Synonyms

D22S673; HC II; HC-II; HC2; HCF2; HEP2_HUMAN; Heparin cofactor 2; Heparin cofactor II; HLS2; Leuserpin 2; LS2; Protease inhibitor leuserpin 2; Protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1; Serpin D1; serpin peptidase inhibitor, clade D (heparin cofactor), member 1; SERPIND1; THPH10

Target Background

This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency.