Recombinant Human Histone deacetylase 11 (HDAC11)

Uniprot Id

Q96DB2

Target Species

Human

Target Name

HDAC11

Target Full Name

Histone deacetylase 11

Target Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Target Subcellular Location

Nucleus. Note=Predominantly nuclear.

Target Protein Families

Histone deacetylase family

Target Tissue Specificity

Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

FLJ22237; HD 11; HD11; HDA11_HUMAN; HDAC 11; HDAC11; Histone deacetylase 11

Target Background

This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.