Recombinant Human Histone H2B type 1-B (H2BC3)

Uniprot Id

P33778

Target Species

Human

Target Name

H2BC3

Target Full Name

Histone H2B type 1-B

Target Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Target Subcellular Location

Nucleus. Chromosome.

Target Protein Families

Histone H2B family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

HIST1H2BB; H2BFFHistone H2B type 1-B; Histone H2B.1; Histone H2B.f; H2B/f

Target Background

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.