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| Cat.No | ACP05615 | Target Name | LEMD3 |
|---|---|---|---|
| Target Synonyms | Inner nuclear membrane protein Man1; LEM domain containing protein 3 ; LEM domain-containing protein 3; LEMD3; MAN1_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y2U8 |
|---|
Uniprot Id
Q9Y2U8
Target Species
Human
Target Name
LEMD3
Target Full Name
Inner nuclear membrane protein Man1
Target Function
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.
Target Involvement
Buschke-Ollendorff syndrome (BOS)
Target Subcellular Location
Nucleus inner membrane; Multi-pass membrane protein.
Target Tissue Specificity
Heart, brain, placenta, lung, liver and skeletal muscle.
Target Synonyms
Inner nuclear membrane protein Man1; LEM domain containing protein 3 ; LEM domain-containing protein 3; LEMD3; MAN1_HUMAN
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