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| Cat.No | ACP19597 | Target Name | INTS8 |
|---|---|---|---|
| Target Synonyms | INTS8; C8orf52; Integrator complex subunit 8; Int8; Protein kaonashi-1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q75QN2 |
|---|
Uniprot Id
Q75QN2
Target Species
Human
Target Name
INTS8
Target Full Name
Integrator complex subunit 8
Target Function
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Target Subcellular Location
Nucleus.
Target Protein Families
Integrator subunit 8 family
Target Synonyms
INTS8; C8orf52; Integrator complex subunit 8; Int8; Protein kaonashi-1
Target Background
This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants.
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