Recombinant Human Integrator complex subunit 9 (INTS9)

Uniprot Id

Q9NV88

Target Species

Human

Target Name

INTS9

Target Full Name

Integrator complex subunit 9

Target Function

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.

Target Subcellular Location

Nucleus.

Target Protein Families

Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, INTS9 subfamily

Target Synonyms

CPSF; CPSF2; CPSF2L; FLJ10871; Int9; INT9_HUMAN; Integrator complex subunit 9; INTS 9; INTS9; Protein related to CPSF subunits of 74 kDa; RC 74; RC-74; RC74; Related to CPSF subunits 74 kDa

Target Background

This gene encodes a subunit of the Integrator complex. This protein complex binds the C-terminal domain of RNA polymerase II and likely plays a role in small nuclear RNA processing. The encoded protein has similarities to the subunits of the cleavage and polyadenylation specificity factor complex. Alternatively spliced transcript variants have been described.