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| Cat.No | ACP06554 | Target Name | ITGB5 |
|---|---|---|---|
| Target Synonyms | ITGB5; Integrin beta-5 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P18084 |
|---|
Uniprot Id
P18084
Target Species
Human
Target Name
ITGB5
Target Full Name
Integrin beta-5
Target Function
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Integrin beta chain family
Target Synonyms
ITGB5; Integrin beta-5
Target Background
Ιntegrins, heterodimeric trans-membrane matrix receptors, are mainly involved in the signal transduction and attachments to extra cellular matrix (ECM).†† In ECM they act as a mediator of cell adhesion.† In human, at least 18 α and eight β subunits have been found.† ITGB5 (integrin subunit β 5) helps in facilitation of cancer cell migration, anchorage-independent growth and tumor angiogenesis. Integrin is activated by G-protein-coupled receptors, resulting in the phosphorylation of cytoplasmic domain of the β subunit. The coupled α and β cytoplasmic tails are responsible for maintaining integrin in inactive state.
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