Recombinant Human Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2)

Uniprot Id

P09913

Target Species

Human

Target Name

IFIT2

Target Full Name

Interferon-induced protein with tetratricopeptide repeats 2

Target Function

IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

Target Subcellular Location

Cytoplasm. Endoplasmic reticulum.

Target Protein Families

IFIT family

Target Synonyms

CIG-42; cig42; G10P2; GARG 39 ; Glucocorticoid attenuated response gene 39; IFI 54 ; IFI 54K ; IFI-54K; IFI54 ; IFIT 2; IFIT-2; IFIT2; IFIT2_HUMAN; Interferon induced 54 kDa protein ; Interferon induced protein 54 ; Interferon induced protein with tetratricopeptide repeats 2; Interferon, alpha inducible protein (MW 54kD); Interferon-induced 54 kDa protein; Interferon-induced protein with tetratricopeptide repeats 2; ISG 54 K; ISG 54K; ISG-54 K; ISG54

Target Background

Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum.