Recombinant Human Janus kinase and microtubule-interacting protein 1 (JAKMIP1)

Uniprot Id

Q96N16

Target Species

Human

Target Name

JAKMIP1

Target Full Name

Janus kinase and microtubule-interacting protein 1

Target Function

Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements.

Target Subcellular Location

Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.

Target Protein Families

JAKMIP family

Target Tissue Specificity

Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected

Target Synonyms

FLJ31564; GABA B receptor binding protein; GABA-B receptor-binding protein; GABABRBP; Jak and microtubule interacting protein 1; JAKMIP 1; JAKMIP1; JAMIP1; Janus kinase and microtubule interacting protein 1; Janus kinase and microtubule-interacting protein 1; JKIP1_HUMAN; Marlin 1; Marlin-1; MARLIN1; Multiple alpha-helices and RNA-linker protein 1; Multiple coiled coil GABABR1 binding protein; OTTHUMP00000155144; OTTHUMP00000203209; OTTHUMP00000203210; OTTHUMP00000203212; OTTHUMP00000217225; OTTHUMP00000217781

Target Background

Enables GABA receptor binding activity and RNA binding activity. Involved in cognition. Is extrinsic component of membrane. Part of ribonucleoprotein complex.