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| Cat.No | ACP09883 | Target Name | KLHL21 |
|---|---|---|---|
| Target Synonyms | Kelch-like protein 21; KIAA0469; KLH21_HUMAN; KLHL21; MGC99635 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-597 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UJP4 |
|---|
Uniprot Id
Q9UJP4
Target Species
Human
Target Name
KLHL21
Target Full Name
Kelch-like protein 21
Target Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.
Target Subcellular Location
Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle midzone and targets CUL3 to this region.
Target Synonyms
Kelch-like protein 21; KIAA0469; KLH21_HUMAN; KLHL21; MGC99635
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