Recombinant Human Laccase domain-containing protein 1 (LACC1)

Cat.No	ACP15069	Target Name	LACC1
Target Synonyms	C13orf31; Chromosome 13 open reading frame 31; CM031_HUMAN; Hypothetical protein LOC144811; UPF0124 protein C13orf31	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-430
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP15069

Target Name

LACC1

Target Synonyms

C13orf31; Chromosome 13 open reading frame 31; CM031_HUMAN; Hypothetical protein LOC144811; UPF0124 protein C13orf31

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-430

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8IV20

Background Information

Uniprot Id

Q8IV20
Target Species

Human
Target Name

LACC1
Target Full Name

Purine nucleoside phosphorylase LACC1
Target Function

Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine. Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate. Also has adenosine deaminase activity. Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages. Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface. The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity. Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance. Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR). Does not show laccase activity
Target Involvement

Rheumatoid arthritis systemic juvenile (RASJ)
Target Subcellular Location

Cytoplasm. Nucleus. Endoplasmic reticulum. Peroxisome.
Target Protein Families

LACC1 family
Target Tissue Specificity

Ubiquitously expressed, with higher expression levels in immune-related tissues such as lymph nodes and spleen. Expressed in both intestinal and peripheral myeloid-derived cells.
Target Synonyms

C13orf31; Chromosome 13 open reading frame 31; CM031_HUMAN; Hypothetical protein LOC144811; UPF0124 protein C13orf31

Recombinant Human Laccase domain-containing protein 1 (LACC1)

Specifications

Immunogen Information

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