Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP01980 | Target Name | LSS |
|---|---|---|---|
| Target Synonyms | 2, 3-epoxysqualene--lanosterol cyclase Oxidosqualene--lanosterol cyclase | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 2-732aa |
| Mol Weight | 89.2 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P48449 |
|---|
Uniprot Id
P48449
Target Species
Human
Target Name
LSS
Target Full Name
Lanosterol synthase
Target Function
Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.
Target Involvement
Cataract 44 (CTRCT44)
Target Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein.
Target Protein Families
Terpene cyclase/mutase family
Target Tissue Specificity
Widely expressed. Expressed in the hair bulb, the outer root sheath and hair matrix of the hair follicle epithelium. Also detected in dermal papilla, epidermis, sweat glands, sebaceous glands, and blood vessels.
Target Research Area
Signal Transduction
Target Synonyms
LSS; OSCLanosterol synthase; EC 5.4.99.7; 2,3-epoxysqualene--lanosterol cyclase; Oxidosqualene--lanosterol cyclase; OSC; hOSC
Target Background
The protein encoded by this gene catalyzes the conversion of (S)-2, 3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
