Recombinant Human LIM and calponin homology domains-containing protein 1 (LIMCH1), Truncated

Uniprot Id

Q9UPQ0

Target Species

Human

Target Name

LIMCH1

Target Full Name

LIM and calponin homology domains-containing protein 1

Target Function

Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.

Target Subcellular Location

Cytoplasm, cytoskeleton, stress fiber.

Target Protein Families

LIMCH1 family

Target Synonyms

DKFZp434I0312; DKFZp686A01247; DKFZp686B2470; DKFZp686G18243; DKFZp686G2094; DKFZp781C1754; DKFZp781I1455; KIAA1102; LIM and calponin homology domains 1; LIM and calponin homology domains containing protein 1; LIM and calponin homology domains-containing protein 1; LIMC1_HUMAN; LIMCH 1; limch1; LIMCH1A; LMO7B; MGC72127; OTTHUMP00000218619

Target Background

Enables myosin II head/neck binding activity. Involved in several processes, including cytoplasmic actin-based contraction involved in cell motility; positive regulation of stress fiber assembly; and regulation of focal adhesion assembly. Located in stress fiber. Colocalizes with myosin II complex.