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Amino acids 21-162 constitute the expression domain of recombinant Human LY86. The expected molecular weight for the LY86 protein is calculated to be 23.1 kDa. This LY86 protein is produced using e.coli expression system. The LY86 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant LY86 protein in following stages of expression and purification.Lymphocyte antigen 86 (LY86), also known as MD-1, is a protein involved in the regulation of immune responses. LY86 is a co-receptor for TLR4 and plays a crucial role in the recognition of bacterial lipopolysaccharides (LPS), triggering the activation of the immune system. As a part of the TLR4 signaling complex, LY86 contributes to the initiation of inflammatory responses by promoting the production of pro-inflammatory cytokines and type I interferons. Its involvement in these processes highlights its significance in the innate immune system's ability to detect and respond to bacterial infections.
Amino acids 21-162 constitute the expression domain of recombinant Human LY86. The expected molecular weight for the LY86 protein is calculated to be 23.1 kDa. This LY86 protein is produced using e.coli expression system. The LY86 coding gene included the N-terminal 10xHis tag and C-terminal Myc tag, which simplifies the detection and purification processes of the recombinant LY86 protein in following stages of expression and purification.Lymphocyte antigen 86 (LY86), also known as MD-1, is a protein involved in the regulation of immune responses. LY86 is a co-receptor for TLR4 and plays a crucial role in the recognition of bacterial lipopolysaccharides (LPS), triggering the activation of the immune system. As a part of the TLR4 signaling complex, LY86 contributes to the initiation of inflammatory responses by promoting the production of pro-inflammatory cytokines and type I interferons. Its involvement in these processes highlights its significance in the innate immune system’s ability to detect and respond to bacterial infections.
| Cat.No | ACP00886 | Target Name | LY86 |
|---|---|---|---|
| Target Synonyms | (Ly-86)(Protein MD-1) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 21-162aa |
| Mol Weight | 23.1 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95711 |
|---|
Uniprot Id
O95711
Target Species
Human
Target Name
LY86
Target Full Name
Lymphocyte antigen 86
Target Function
May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.
Target Subcellular Location
Secreted, extracellular space. Note=Associated with CD180 at the cell surface.
Target Tissue Specificity
Highly expressed in B-cells, monocytes and tonsil.
Target Research Area
Immunology
Target Synonyms
BPAD; dJ80N2.1; Ly 86; Ly-86; Ly86; LY86_HUMAN; Lymphocyte antigen 86; Lymphocyte antigen 86 precursor; Major affective disorder 1; MD 1; MD-1; MD1 protein; MD1 RP105 associated ; MMD 1; MMD-1; Protein MD 1; Protein MD-1; RP1-80N2.1
Target Background
Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular space.
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