Recombinant Human Lysine-specific demethylase 4A (KDM4A), Truncated

Uniprot Id

O75164

Target Species

Human

Target Name

KDM4A

Target Full Name

Lysine-specific demethylase 4A

Target Function

Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.; Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.

Target Subcellular Location

Nucleus.

Target Protein Families

JHDM3 histone demethylase family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

JHDM3A; JmjC domain containing histone demethylation protein 3A; JmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain containing histone demethylase 3A ; Jumonji domain containing 2; Jumonji domain containing 2A; Jumonji domain containing protein 2A; Jumonji domain-containing protein 2A; KDM4A; KDM4A_HUMAN; KIAA0677; Lysine (K) specific demethylase 4A; Lysine-specific demethylase 4A; TDRD14A; Tudor domain containing 14A

Target Background

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.