Recombinant Human Lysosomal Pro-X carboxypeptidase (PRCP)

Uniprot Id

P42785

Target Species

Human

Target Name

PRCP

Target Full Name

Lysosomal Pro-X carboxypeptidase

Target Function

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.

Target Subcellular Location

Lysosome.

Target Protein Families

Peptidase S28 family

Target Tissue Specificity

Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.

Target Synonyms

Angiotensinase C; HUMPCP ; Lysosomal carboxypeptidase C; Lysosomal Pro X carboxypeptidase; Lysosomal Pro-X carboxypeptidase; MGC2202; PCP ; PCP_HUMAN; PRCP; Proline carboxypeptidase; Prolylcarboxypeptidase (angiotensinase C); Prolylcarboxypeptidase; prolylcarboxypeptidase isoform 1 preproprotein

Target Background

This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.