Recombinant Human Lysyl oxidase homolog 4 (LOXL4)

Uniprot Id

Q96JB6

Target Species

Human

Target Name

LOXL4

Target Full Name

Lysyl oxidase homolog 4

Target Function

May modulate the formation of a collagenous extracellular matrix.

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

Lysyl oxidase family

Target Tissue Specificity

Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage.

Target Research Area

Signal Transduction

Target Synonyms

4833426I20Rik; FLJ21889; LOX L4; LOXC; LOXL 4; LOXL4; LOXL4_HUMAN; Lysyl oxidase homolog 4; Lysyl oxidase like 4; Lysyl oxidase like protein 4; Lysyl oxidase related C; Lysyl oxidase related protein C; Lysyl oxidase-like protein 4; Lysyl oxidase-related protein C

Target Background

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.