Recombinant Human Matrix metalloproteinase-19 (MMP19)

Uniprot Id

Q99542

Target Species

Human

Target Name

MMP19

Target Full Name

Matrix metalloproteinase-19

Target Function

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

Target Involvement

Cavitary optic disc anomalies (CODA)

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Protein Families

Peptidase M10A family

Target Tissue Specificity

Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and r

Target Synonyms

Matrix metalloproteinase 18 ; Matrix metalloproteinase 19 isoform rasi1; Matrix metalloproteinase 19 isoform rasi9; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; Matrix metalloproteinase-19; MMP-18; MMP-19; MMP18; MMP19; MMP19_HUMAN; Preproprotein matrix metalloproteinase 19 isoform rasi6; RASI 1; RASI1

Target Background

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene.