Recombinant Human Mediator of RNA polymerase II transcription subunit 6 (MED6)

Uniprot Id

O75586

Target Species

Human

Target Name

MED6

Target Full Name

Mediator of RNA polymerase II transcription subunit 6

Target Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Target Subcellular Location

Nucleus.

Target Protein Families

Mediator complex subunit 6 family

Target Synonyms

Activator recruited cofactor 33 kDa; Activator-recruited cofactor 33 kDa component; ARC33; hMed6; MED6; MED6_HUMAN; Mediator complex subunit 6; Mediator of RNA polymerase II transcription subunit 6; NY REN 28; NY REN 28 antigen; Renal carcinoma antigen NY-REN-28; RNA polymerase transcriptional regulation mediator subunit 6

Target Background

Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of mediator complex.