Recombinant Human Melanin-concentrating hormone receptor 1 (MCHR1), Truncated

Uniprot Id

Q99705

Target Species

Human

Target Name

MCHR1

Target Full Name

Melanin-concentrating hormone receptor 1

Target Function

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

G-protein coupled receptor 1 family

Target Tissue Specificity

Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Target Synonyms

MCHR1; GPR24; SLC1; Melanin-concentrating hormone receptor 1; MCH receptor 1; MCH-R1; MCHR-1; G-protein coupled receptor 24; MCH-1R; MCH1R; MCHR; SLC-1; Somatostatin receptor-like protein

Target Background

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.