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| Cat.No | ACP21066 | Target Name | TRMU |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-421 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75648 |
|---|
Uniprot Id
O75648
Target Species
Human
Target Name
TRMU
Target Full Name
Mitochondrial tRNA-specific 2-thiouridylase 1
Target Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Target Involvement
Liver failure, infantile, transient (LFIT)
Target Subcellular Location
Mitochondrion.
Target Protein Families
MnmA/TRMU family
Target Tissue Specificity
Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain.
Target Synonyms
LCAL3; MGC99627; Mitochondrial tRNA specific 2 thiouridylase 1; Mitochondrial tRNA-specific 2-thiouridylase 1; MTO 2; MTO2; MTO2 homolog; MTU 1; MTU1; MTU1_HUMAN; TRMT 1; TRMT; trmu; tRNA (5 methylaminomethyl 2 thiouridylate) methyltransferase; tRNA 5 methylaminomethyl 2 thiouridylate methyltransferase; TRNT 1; TRNT1
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