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Discover the exceptional quality of our Recombinant Human SMAD6 protein, specifically designed to support your epigenetics and nuclear signaling research. This full-length protein (1-496aa) is expressed in E. coli, and features both an N-terminal 10xHis-tag and a C-terminal Myc-tag, ensuring straightforward purification and detection. Our SMAD6 protein boasts a purity of greater than 85% as determined by SDS-PAGE, providing you with a reliable and consistent product for your research needs. Unveil the intricate functions of Mothers against decapentaplegic homolog 6 with our top-notch recombinant protein. Available in both liquid and lyophilized powder forms, our Recombinant Human SMAD6 protein delivers the versatility and quality you require to drive your research forward and achieve new insights.
Discover the exceptional quality of our Recombinant Human SMAD6 protein, specifically designed to support your epigenetics and nuclear signaling research. This full-length protein (1-496aa) is expressed in E. coli, and features both an N-terminal 10xHis-tag and a C-terminal Myc-tag, ensuring straightforward purification and detection. Our SMAD6 protein boasts a purity of greater than 85% as determined by SDS-PAGE, providing you with a reliable and consistent product for your research needs.
Unveil the intricate functions of Mothers against decapentaplegic homolog 6 with our top-notch recombinant protein. Available in both liquid and lyophilized powder forms, our Recombinant Human SMAD6 protein delivers the versatility and quality you require to drive your research forward and achieve new insights.
| Cat.No | ACP05116 | Target Name | SMAD6 |
|---|---|---|---|
| Target Synonyms | hSMAD6; MAD homolog 6; MADH6; MADH7; Mothers against decapentaplegic homolog 6; Mothers against DPP homolog 6; SMAD 6; SMAD family member 6; SMAD mothers against DPP homolog 6; Smad6; SMAD6_HUMAN | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-496aa |
| Mol Weight | 60.9 kDa | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O43541 |
|---|
Uniprot Id
O43541
Target Species
Human
Target Name
SMAD6
Target Full Name
Mothers against decapentaplegic homolog 6
Target Function
Transforming growth factor-beta superfamily receptors signaling occurs through the Smad family of intracellular mediators. SMAD6 is an inhibitory Smad (i-Smad) that negatively regulates signaling downstream of type I transforming growth factor-beta. Acts as a mediator of TGF-beta and BMP anti-inflammatory activities. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions.
Target Involvement
Aortic valve disease 2 (AOVD2); Craniosynostosis 7 (CRS7)
Target Subcellular Location
Nucleus.
Target Protein Families
Dwarfin/SMAD family
Target Tissue Specificity
Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
hSMAD6; MAD homolog 6; MADH6; MADH7; Mothers against decapentaplegic homolog 6; Mothers against DPP homolog 6; SMAD 6; SMAD family member 6; SMAD mothers against DPP homolog 6; Smad6; SMAD6_HUMAN
Target Background
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.
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