Recombinant Human Msx2-interacting protein (SPEN), Truncated

Uniprot Id

Q96T58

Target Species

Human

Target Name

SPEN

Target Full Name

Msx2-interacting protein

Target Function

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA

Target Subcellular Location

Nucleus. Note=Associates with chromatin.

Target Protein Families

RRM Spen family

Target Tissue Specificity

Expressed at high level in brain, testis, spleen and thymus. Expressed at intermediate level in kidney, liver, mammary gland and skin.

Target Synonyms

SPEN; KIAA0929; MINT; SHARP; Msx2-interacting protein; SMART/HDAC1-associated repressor protein; SPEN homolog