Recombinant Human Multidrug resistance-associated protein 7 (ABCC10), Truncated

Uniprot Id

Q5T3U5

Target Species

Human

Target Name

ABCC10

Target Full Name

ATP-binding cassette sub-family C member 10

Target Function

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel. Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily

Target Tissue Specificity

[Isoform 1]: Specifically expressed in spleen.; [Isoform 2]: Widely expressed.

Target Synonyms

ABCC10; ATP binding cassette; sub family C (CFTR/MRP); member 10 ; ATP binding cassette; subfamily C; member 10 ; ATP-binding cassette sub-family C member 10; EST182763; mFLJ00002; MRP7 ; MRP7_HUMAN; Multidrug resistance associated protein 7; Multidrug resistance-associated protein 7; SIMRP7