Recombinant Human Myotubularin-related protein 9 (MTMR9)

Cat.No	ACP13443	Target Name	MTMR9
Target Synonyms	MTMR9; C8orf9; MTMR8; Myotubularin-related protein 9; Inactive phosphatidylinositol 3-phosphatase 9	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-549
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP13443

Target Name

MTMR9

Target Synonyms

MTMR9; C8orf9; MTMR8; Myotubularin-related protein 9; Inactive phosphatidylinositol 3-phosphatase 9

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-549

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96QG7

Background Information

Uniprot Id

Q96QG7
Target Species

Human
Target Name

MTMR9
Target Full Name

Myotubularin-related protein 9
Target Function

Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity. Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine.
Target Subcellular Location

Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Endoplasmic reticulum.
Target Protein Families

Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Target Tissue Specificity

Expressed in many tissues.
Target Synonyms

MTMR9; C8orf9; MTMR8; Myotubularin-related protein 9; Inactive phosphatidylinositol 3-phosphatase 9
Target Background

This gene encodes a myotubularin-related protein that is atypical to most other members of the myotubularin-related protein family because it has no dual-specificity phosphatase domain. The encoded protein contains a double-helical motif similar to the SET interaction domain, which is thought to have a role in the control of cell proliferation. In mouse, a protein similar to the encoded protein binds with MTMR7, and together they dephosphorylate phosphatidylinositol 3-phosphate and inositol 1, 3-bisphosphate.

Recombinant Human Myotubularin-related protein 9 (MTMR9)

Specifications

Immunogen Information

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