Recombinant Human Myozenin-1 (MYOZ1)

Uniprot Id

Q9NP98

Target Species

Human

Target Name

MYOZ1

Target Full Name

Myozenin-1

Target Function

Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.

Target Subcellular Location

Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle.

Target Protein Families

Myozenin family

Target Tissue Specificity

Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas.

Target Synonyms

actinin- and telethonin-binding protein; Calsarcin 2; Calsarcin-2; CS 2; FATZ; Filamin, actinin and telethonin binding protein; Filamin-; MYOZ; MYOZ1; MYOZ1_HUMAN; Myozenin-1; Protein FATZ

Target Background

The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling.