Recombinant Human N-alpha-acetyltransferase 60 (NAA60), Truncated

Uniprot Id

Q9H7X0

Target Species

Human

Target Name

NAA60

Target Full Name

N-alpha-acetyltransferase 60

Target Function

N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences.

Target Subcellular Location

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Acetyltransferase family, NAA60 subfamily

Target Synonyms

FLJ11693; FLJ14154; HAT4; Histone acetyltransferase type B protein 4; N acetyltransferase 15 (GCN5 related, putative); N alpha acetyltransferase 60; N(alpha) acetyltransferase 60, NatF catalytic subunit; N-acetyltransferase 15; N-alpha-acetyltransferase 60; naa60; NAA60_HUMAN; NAT15; NatF catalytic subunit

Target Background

This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele.