Recombinant Human N-myc proto-oncogene protein (MYCN)

Uniprot Id

P04198

Target Species

Human

Target Name

MYCN

Target Full Name

N-myc proto-oncogene protein

Target Function

Positively regulates the transcription of MYCNOS in neuroblastoma cells.

Target Involvement

Feingold syndrome 1 (FGLDS1)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level).

Target Research Area

Cancer

Target Synonyms

bHLHe37; Class E basic helix-loop-helix protein 37; MODED; mycn; MYCN_HUMAN; N myc; N myc proto oncogene protein; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene; Neuroblastoma MYC oncogene; NMYC; NMYC proto oncogene protein; ODED; Oncogene NMYC; pp65/67; V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v myc avian myelocytomatosis viral related oncogene neuroblastoma derived; v myc myelocytomatosis viral related oncogene neuroblastoma derived

Target Background

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.