Recombinant Human NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1)

Cat.No	ACP23707	Target Name	NDUFS1
Target Synonyms	CI-75kD; Complex I 75Kd; Complex I, mitochondrial respiratory chain	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	24-727
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP23707

Target Name

NDUFS1

Target Synonyms

CI-75kD; Complex I 75Kd; Complex I, mitochondrial respiratory chain

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

24-727

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P28331

Background Information

Uniprot Id

P28331
Target Species

Human
Target Name

NDUFS1
Target Full Name

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Target Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for catalysing the entry and efficient transfer of electrons within complex I. Plays a key role in the assembly and stability of complex I and participates in the association of complex I with ubiquinol-cytochrome reductase complex (Complex III) to form supercomplexes.
Target Involvement

Mitochondrial complex I deficiency (MT-C1D)
Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Target Protein Families

Complex I 75 kDa subunit family
Target Synonyms

CI-75kD; Complex I 75Kd; Complex I, mitochondrial respiratory chain, 75 kD subunit; Complex I-75kD; mitochondrial; NADH coenzyme Q reductase; NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial ; NADH-ubiquinone oxidoreductase 75 kDa subunit; NDUFS1; NDUS1_HUMAN; PRO1304
Target Background

The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. Mutations in this gene are associated with complex I deficiency. Several transcript variants encoding different isoforms have been found for this gene.

Recombinant Human NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1)

Specifications

Immunogen Information

Inquire Recombinant Human NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) Now

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