Recombinant Human Neuralized-like protein 2 (NEURL2)

Uniprot Id

Q9BR09

Target Species

Human

Target Name

NEURL2

Target Full Name

Neuralized-like protein 2

Target Function

Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma.

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Expressed specifically in skeletal and cardiac muscles.

Target Synonyms

NEURL2; C20orf163; Neuralized-like protein 2

Target Background

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants.