Recombinant Human Neuroligin-4, X-linked (NLGN4X), Truncated

Uniprot Id

Q8N0W4

Target Species

Human

Target Name

NLGN4X

Target Full Name

Neuroligin-4, X-linked

Target Function

Putative neuronal cell surface protein involved in cell-cell-interactions.

Target Involvement

Autism, X-linked 2 (AUTSX2); Asperger syndrome, X-linked, 2 (ASPGX2)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density membrane.

Target Protein Families

Type-B carboxylesterase/lipase family

Target Tissue Specificity

Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.

Target Synonyms

ASPGX2; AUTSX2; HLNX; HNL4X; HNLX; KIAA1260; neuroligin 4, X-linked; Neuroligin X; Neuroligin-4; NL4; NLGN; NLGN4; NLGN4X; NLGNX_HUMAN; OTTHUMP00000022863; OTTHUMP00000022864; OTTHUMP00000022865; X-linked

Target Background

This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants.