Recombinant Human Neuronal acetylcholine receptor subunit alpha-2 (CHRNA2), Truncated

Uniprot Id

Q15822

Target Species

Human

Target Name

CHRNA2

Target Full Name

Neuronal acetylcholine receptor subunit alpha-2

Target Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Target Involvement

Epilepsy, nocturnal frontal lobe, 4 (ENFL4)

Target Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-2/CHRNA2 sub-subfamily

Target Synonyms

ACHA2_HUMAN; AChR; Cholinergic receptor nicotinic alpha 2; Chrna2; Neuronal acetylcholine receptor protein subunit alpha 2; Neuronal acetylcholine receptor subunit alpha-2; Nicotinic Acetylcholine Receptor alpha 2

Target Background

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.