Recombinant Human Neuropeptide S receptor (NPSR1), Truncated

Uniprot Id

Q6W5P4

Target Species

Human

Target Name

NPSR1

Target Full Name

Neuropeptide S receptor

Target Function

G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pathogenesis of asthma and other IgE-mediated diseases.

Target Involvement

Asthma-related traits 2 (ASRT2)

Target Subcellular Location

[Isoform 1]: Cell membrane; Multi-pass membrane protein.; [Isoform 3]: Cell membrane; Multi-pass membrane protein.; [Isoform 4]: Cell membrane; Multi-pass membrane protein.; [Isoform 2]: Cytoplasm.; [Isoform 5]: Cytoplasm.; [Isoform 6]: Cytoplasm.; [Isoform 7]: Cytoplasm.; [Isoform 9]: Cytoplasm.

Target Protein Families

G-protein coupled receptor 1 family, Vasopressin/oxytocin receptor subfamily

Target Tissue Specificity

Isoform 4 is ubiquitous; it is detected in glandular epithelia of bronchus, stomach, small intestine, colon, uterus, esophagus, spleen, kidney, pancreas, prostate and breast. Isoform 1 is detected in uterus, colon and prostate, and in the smooth muscle ce

Target Synonyms

NPSR1; GPR154; GPRA; PGR14; Neuropeptide S receptor; G-protein coupled receptor 154; G-protein coupled receptor PGR14; G-protein coupled receptor for asthma susceptibility

Target Background

This gene encodes a member of the vasopressin/oxytocin subfamily of G protein-coupled receptors. The encoded membrane protein acts as a receptor for neuropeptide S and affects a variety of cellular processes through its signaling. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Polymorphisms in this gene have also been associated with asthma susceptibility, panic disorders, inflammatory bowel disease, and rheumatoid arthritis. Alternative splicing results in multiple transcript variants.