Recombinant Human Neutrophil cytosol factor 2 (NCF2)

Uniprot Id

P19878

Target Species

Human

Target Name

NCF2

Target Full Name

Neutrophil cytosol factor 2

Target Function

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).

Target Involvement

Granulomatous disease, chronic, cytochrome-b-positive 2, autosomal recessive (CGD2)

Target Subcellular Location

Cytoplasm.

Target Protein Families

NCF2/NOXA1 family

Target Synonyms

67 kDa neutrophil oxidase factor; Chronic granulomatous disease autosomal 2; FLJ93058; NADPH oxidase activator 2; NCF-2; Ncf2; NCF2_HUMAN; Neutrophil cytosol factor 2; Neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; NOXA2; P67 PHOX; p67-phox; p67phox

Target Background

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.